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Wham is created for paired-stop Illumina libraries with common insert dimensions (~300bp-500bp). Wham integrates mate-pair mapping, break up go through mapping, comfortable-clipping, alternate alignment and consensus sequence centered proof to predict SV breakpoints with one-nucleotide accuracy. Wham generates a blended pileup (catalog of reads mas

The delicate-clipped sequences that overhang the breakpoint are collapsed right into a consensus sequence using a numerous sequence alignment (MSA) provided in the seqAn library [27]. Wham applies 3 filters on the consensus sequences. Breakpoints aren't claimed in scenarios in which consensus sequences are shorter than ten bp or comprise a lot more

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